Impact of common risk factors of fibrosis progression in chronic hepatitis C.
Identifieur interne : 002C60 ( Main/Exploration ); précédent : 002C59; suivant : 002C61Impact of common risk factors of fibrosis progression in chronic hepatitis C.
Auteurs : S. Rüeger [Suisse] ; P-Y Bochud [Suisse] ; J-F Dufour [Suisse] ; B. Müllhaupt [Suisse] ; D. Semela [Suisse] ; M H Heim [Suisse] ; D. Moradpour [Suisse] ; A. Cerny [Suisse] ; R. Malinverni [Suisse] ; D R Booth [Australie] ; V. Suppiah [Australie] ; J. George [Australie] ; L. Argiro [France] ; P. Halfon [France] ; M. Bourlière [France] ; A H Talal [États-Unis] ; I M Jacobson [États-Unis] ; E. Patin [France] ; B. Nalpas [France] ; T. Poynard [France] ; S. Pol [France] ; L. Abel [États-Unis] ; Z. Kutalik [Suisse] ; F. Negro [Suisse]Source :
- Gut [ 1468-3288 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Biopsie, Cirrhose du foie (diagnostic), Cirrhose du foie (épidémiologie), Cirrhose du foie (étiologie), Facteurs de risque, Facteurs temps, Femelle, Hepacivirus (génétique), Humains, Hépatite C chronique (), Hépatite C chronique (virologie), Incidence, Mâle, Polymorphisme de nucléotide simple, Suisse (épidémiologie), Étude d'association pangénomique, Études rétrospectives, Évaluation des risques (), Évolution de la maladie.
- MESH :
- analyse : ARN viral.
- diagnostic : Cirrhose du foie.
- génétique : Hepacivirus.
- virologie : Hépatite C chronique.
- épidémiologie : Cirrhose du foie, Suisse.
- étiologie : Cirrhose du foie.
- Biopsie, Facteurs de risque, Facteurs temps, Femelle, Humains, Hépatite C chronique, Incidence, Mâle, Polymorphisme de nucléotide simple, Étude d'association pangénomique, Études rétrospectives, Évaluation des risques, Évolution de la maladie.
- Wicri :
- geographic : Suisse.
English descriptors
- KwdEn :
- Biopsy, Disease Progression, Female, Genome-Wide Association Study, Hepacivirus (genetics), Hepatitis C, Chronic (complications), Hepatitis C, Chronic (virology), Humans, Incidence, Liver Cirrhosis (diagnosis), Liver Cirrhosis (epidemiology), Liver Cirrhosis (etiology), Male, Polymorphism, Single Nucleotide, RNA, Viral (analysis), Retrospective Studies, Risk Assessment (methods), Risk Factors, Switzerland (epidemiology), Time Factors.
- MESH :
- chemical , analysis : RNA, Viral.
- geographic , epidemiology : Switzerland.
- complications : Hepatitis C, Chronic.
- diagnosis : Liver Cirrhosis.
- epidemiology : Liver Cirrhosis.
- etiology : Liver Cirrhosis.
- genetics : Hepacivirus.
- methods : Risk Assessment.
- virology : Hepatitis C, Chronic.
- Biopsy, Disease Progression, Female, Genome-Wide Association Study, Humans, Incidence, Male, Polymorphism, Single Nucleotide, Retrospective Studies, Risk Factors, Time Factors.
Abstract
The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C.
DOI: 10.1136/gutjnl-2014-306997
PubMed: 25214320
Affiliations:
- Australie, France, Suisse, États-Unis
- Canton de Berne, Canton de Vaud, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, État de New York, Île-de-France
- Berne, Lausanne, Marseille, Paris, Sydney
- Université Pierre-et-Marie-Curie, Université de Sydney, Université de la Méditerranée
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Le document en format XML
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Rüeger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Bochud, P Y" sort="Bochud, P Y" uniqKey="Bochud P" first="P-Y" last="Bochud">P-Y Bochud</name><affiliation wicri:level="3"><nlm:affiliation>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Dufour, J F" sort="Dufour, J F" uniqKey="Dufour J" first="J-F" last="Dufour">J-F Dufour</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hepatology, University of Berne, Berne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Hepatology, University of Berne, Berne</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Mullhaupt, B" sort="Mullhaupt, B" uniqKey="Mullhaupt B" first="B" last="Müllhaupt">B. 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Semela</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Canton Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology, Canton Hospital St Gallen, St Gallen</wicri:regionArea><wicri:noRegion>St Gallen</wicri:noRegion></affiliation></author><author><name sortKey="Heim, M H" sort="Heim, M H" uniqKey="Heim M" first="M H" last="Heim">M H Heim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Moradpour, D" sort="Moradpour, D" uniqKey="Moradpour D" first="D" last="Moradpour">D. Moradpour</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Cerny, A" sort="Cerny, A" uniqKey="Cerny A" first="A" last="Cerny">A. Cerny</name><affiliation wicri:level="1"><nlm:affiliation>Epatologia, Clinica Moncucco, Lugano, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Epatologia, Clinica Moncucco, Lugano</wicri:regionArea><wicri:noRegion>Lugano</wicri:noRegion></affiliation></author><author><name sortKey="Malinverni, R" sort="Malinverni, R" uniqKey="Malinverni R" first="R" last="Malinverni">R. Malinverni</name><affiliation wicri:level="1"><nlm:affiliation>Pourtalès Hospital, Neuchatel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pourtalès Hospital, Neuchatel</wicri:regionArea><wicri:noRegion>Neuchatel</wicri:noRegion></affiliation></author><author><name sortKey="Booth, D R" sort="Booth, D R" uniqKey="Booth D" first="D R" last="Booth">D R Booth</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Suppiah, V" sort="Suppiah, V" uniqKey="Suppiah V" first="V" last="Suppiah">V. Suppiah</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="George, J" sort="George, J" uniqKey="George J" first="J" last="George">J. George</name><affiliation wicri:level="3"><nlm:affiliation>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Argiro, L" sort="Argiro, L" uniqKey="Argiro L" first="L" last="Argiro">L. Argiro</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><orgName type="university">Université de la Méditerranée</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Halfon, P" sort="Halfon, P" uniqKey="Halfon P" first="P" last="Halfon">P. Halfon</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><wicri:noRegion>Marseilles</wicri:noRegion></affiliation></author><author><name sortKey="Bourliere, M" sort="Bourliere, M" uniqKey="Bourliere M" first="M" last="Bourlière">M. Bourlière</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><wicri:noRegion>Marseilles</wicri:noRegion></affiliation></author><author><name sortKey="Talal, A H" sort="Talal, A H" uniqKey="Talal A" first="A H" last="Talal">A H Talal</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Jacobson, I M" sort="Jacobson, I M" uniqKey="Jacobson I" first="I M" last="Jacobson">I M Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Patin, E" sort="Patin, E" uniqKey="Patin E" first="E" last="Patin">E. Patin</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Nalpas, B" sort="Nalpas, B" uniqKey="Nalpas B" first="B" last="Nalpas">B. Nalpas</name><affiliation wicri:level="3"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Poynard, T" sort="Poynard, T" uniqKey="Poynard T" first="T" last="Poynard">T. Poynard</name><affiliation wicri:level="4"><nlm:affiliation>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S" last="Pol">S. Pol</name><affiliation wicri:level="3"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Abel, L" sort="Abel, L" uniqKey="Abel L" first="L" last="Abel">L. Abel</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kutalik, Z" sort="Kutalik, Z" uniqKey="Kutalik Z" first="Z" last="Kutalik">Z. Kutalik</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Negro, F" sort="Negro, F" uniqKey="Negro F" first="F" last="Negro">F. Negro</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25214320</idno><idno type="pmid">25214320</idno><idno type="doi">10.1136/gutjnl-2014-306997</idno><idno type="wicri:Area/PubMed/Corpus">002921</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002921</idno><idno type="wicri:Area/PubMed/Curation">002852</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002852</idno><idno type="wicri:Area/PubMed/Checkpoint">002852</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002852</idno><idno type="wicri:Area/Ncbi/Merge">001D93</idno><idno type="wicri:Area/Ncbi/Curation">001D93</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D93</idno><idno type="wicri:Area/Main/Merge">002C60</idno><idno type="wicri:Area/Main/Curation">002C60</idno><idno type="wicri:Area/Main/Exploration">002C60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of common risk factors of fibrosis progression in chronic hepatitis C.</title><author><name sortKey="Rueger, S" sort="Rueger, S" uniqKey="Rueger S" first="S" last="Rüeger">S. Rüeger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Bochud, P Y" sort="Bochud, P Y" uniqKey="Bochud P" first="P-Y" last="Bochud">P-Y Bochud</name><affiliation wicri:level="3"><nlm:affiliation>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Dufour, J F" sort="Dufour, J F" uniqKey="Dufour J" first="J-F" last="Dufour">J-F Dufour</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hepatology, University of Berne, Berne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Hepatology, University of Berne, Berne</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Mullhaupt, B" sort="Mullhaupt, B" uniqKey="Mullhaupt B" first="B" last="Müllhaupt">B. Müllhaupt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Semela, D" sort="Semela, D" uniqKey="Semela D" first="D" last="Semela">D. Semela</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Canton Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology, Canton Hospital St Gallen, St Gallen</wicri:regionArea><wicri:noRegion>St Gallen</wicri:noRegion></affiliation></author><author><name sortKey="Heim, M H" sort="Heim, M H" uniqKey="Heim M" first="M H" last="Heim">M H Heim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Moradpour, D" sort="Moradpour, D" uniqKey="Moradpour D" first="D" last="Moradpour">D. Moradpour</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Cerny, A" sort="Cerny, A" uniqKey="Cerny A" first="A" last="Cerny">A. Cerny</name><affiliation wicri:level="1"><nlm:affiliation>Epatologia, Clinica Moncucco, Lugano, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Epatologia, Clinica Moncucco, Lugano</wicri:regionArea><wicri:noRegion>Lugano</wicri:noRegion></affiliation></author><author><name sortKey="Malinverni, R" sort="Malinverni, R" uniqKey="Malinverni R" first="R" last="Malinverni">R. Malinverni</name><affiliation wicri:level="1"><nlm:affiliation>Pourtalès Hospital, Neuchatel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pourtalès Hospital, Neuchatel</wicri:regionArea><wicri:noRegion>Neuchatel</wicri:noRegion></affiliation></author><author><name sortKey="Booth, D R" sort="Booth, D R" uniqKey="Booth D" first="D R" last="Booth">D R Booth</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Suppiah, V" sort="Suppiah, V" uniqKey="Suppiah V" first="V" last="Suppiah">V. Suppiah</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="George, J" sort="George, J" uniqKey="George J" first="J" last="George">J. George</name><affiliation wicri:level="3"><nlm:affiliation>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Argiro, L" sort="Argiro, L" uniqKey="Argiro L" first="L" last="Argiro">L. Argiro</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><orgName type="university">Université de la Méditerranée</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Halfon, P" sort="Halfon, P" uniqKey="Halfon P" first="P" last="Halfon">P. Halfon</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><wicri:noRegion>Marseilles</wicri:noRegion></affiliation></author><author><name sortKey="Bourliere, M" sort="Bourliere, M" uniqKey="Bourliere M" first="M" last="Bourlière">M. Bourlière</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><wicri:noRegion>Marseilles</wicri:noRegion></affiliation></author><author><name sortKey="Talal, A H" sort="Talal, A H" uniqKey="Talal A" first="A H" last="Talal">A H Talal</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Jacobson, I M" sort="Jacobson, I M" uniqKey="Jacobson I" first="I M" last="Jacobson">I M Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Patin, E" sort="Patin, E" uniqKey="Patin E" first="E" last="Patin">E. Patin</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Nalpas, B" sort="Nalpas, B" uniqKey="Nalpas B" first="B" last="Nalpas">B. Nalpas</name><affiliation wicri:level="3"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Poynard, T" sort="Poynard, T" uniqKey="Poynard T" first="T" last="Poynard">T. Poynard</name><affiliation wicri:level="4"><nlm:affiliation>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S" last="Pol">S. Pol</name><affiliation wicri:level="3"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Abel, L" sort="Abel, L" uniqKey="Abel L" first="L" last="Abel">L. Abel</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kutalik, Z" sort="Kutalik, Z" uniqKey="Kutalik Z" first="Z" last="Kutalik">Z. Kutalik</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Negro, F" sort="Negro, F" uniqKey="Negro F" first="F" last="Negro">F. Negro</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gut</title><idno type="eISSN">1468-3288</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biopsy</term><term>Disease Progression</term><term>Female</term><term>Genome-Wide Association Study</term><term>Hepacivirus (genetics)</term><term>Hepatitis C, Chronic (complications)</term><term>Hepatitis C, Chronic (virology)</term><term>Humans</term><term>Incidence</term><term>Liver Cirrhosis (diagnosis)</term><term>Liver Cirrhosis (epidemiology)</term><term>Liver Cirrhosis (etiology)</term><term>Male</term><term>Polymorphism, Single Nucleotide</term><term>RNA, Viral (analysis)</term><term>Retrospective Studies</term><term>Risk Assessment (methods)</term><term>Risk Factors</term><term>Switzerland (epidemiology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Biopsie</term><term>Cirrhose du foie (diagnostic)</term><term>Cirrhose du foie (épidémiologie)</term><term>Cirrhose du foie (étiologie)</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Hepacivirus (génétique)</term><term>Humains</term><term>Hépatite C chronique ()</term><term>Hépatite C chronique (virologie)</term><term>Incidence</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Suisse (épidémiologie)</term><term>Étude d'association pangénomique</term><term>Études rétrospectives</term><term>Évaluation des risques ()</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Switzerland</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Cirrhose du foie</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Cirrhose du foie</term><term>Suisse</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Cirrhose du foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Disease Progression</term><term>Female</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Polymorphism, Single Nucleotide</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biopsie</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Hépatite C chronique</term><term>Incidence</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Étude d'association pangénomique</term><term>Études rétrospectives</term><term>Évaluation des risques</term><term>Évolution de la maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suisse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Berne</li><li>Canton de Vaud</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Berne</li><li>Lausanne</li><li>Marseille</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li><li>Université de Sydney</li><li>Université de la Méditerranée</li></orgName></list><tree><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Rueger, S" sort="Rueger, S" uniqKey="Rueger S" first="S" last="Rüeger">S. Rüeger</name></region><name sortKey="Bochud, P Y" sort="Bochud, P Y" uniqKey="Bochud P" first="P-Y" last="Bochud">P-Y Bochud</name><name sortKey="Cerny, A" sort="Cerny, A" uniqKey="Cerny A" first="A" last="Cerny">A. Cerny</name><name sortKey="Dufour, J F" sort="Dufour, J F" uniqKey="Dufour J" first="J-F" last="Dufour">J-F Dufour</name><name sortKey="Heim, M H" sort="Heim, M H" uniqKey="Heim M" first="M H" last="Heim">M H Heim</name><name sortKey="Kutalik, Z" sort="Kutalik, Z" uniqKey="Kutalik Z" first="Z" last="Kutalik">Z. Kutalik</name><name sortKey="Malinverni, R" sort="Malinverni, R" uniqKey="Malinverni R" first="R" last="Malinverni">R. Malinverni</name><name sortKey="Moradpour, D" sort="Moradpour, D" uniqKey="Moradpour D" first="D" last="Moradpour">D. Moradpour</name><name sortKey="Mullhaupt, B" sort="Mullhaupt, B" uniqKey="Mullhaupt B" first="B" last="Müllhaupt">B. Müllhaupt</name><name sortKey="Negro, F" sort="Negro, F" uniqKey="Negro F" first="F" last="Negro">F. Negro</name><name sortKey="Semela, D" sort="Semela, D" uniqKey="Semela D" first="D" last="Semela">D. Semela</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Booth, D R" sort="Booth, D R" uniqKey="Booth D" first="D R" last="Booth">D R Booth</name></region><name sortKey="George, J" sort="George, J" uniqKey="George J" first="J" last="George">J. George</name><name sortKey="Suppiah, V" sort="Suppiah, V" uniqKey="Suppiah V" first="V" last="Suppiah">V. Suppiah</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Argiro, L" sort="Argiro, L" uniqKey="Argiro L" first="L" last="Argiro">L. Argiro</name></region><name sortKey="Bourliere, M" sort="Bourliere, M" uniqKey="Bourliere M" first="M" last="Bourlière">M. Bourlière</name><name sortKey="Halfon, P" sort="Halfon, P" uniqKey="Halfon P" first="P" last="Halfon">P. Halfon</name><name sortKey="Nalpas, B" sort="Nalpas, B" uniqKey="Nalpas B" first="B" last="Nalpas">B. Nalpas</name><name sortKey="Patin, E" sort="Patin, E" uniqKey="Patin E" first="E" last="Patin">E. Patin</name><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S" last="Pol">S. Pol</name><name sortKey="Poynard, T" sort="Poynard, T" uniqKey="Poynard T" first="T" last="Poynard">T. Poynard</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Talal, A H" sort="Talal, A H" uniqKey="Talal A" first="A H" last="Talal">A H Talal</name></region><name sortKey="Abel, L" sort="Abel, L" uniqKey="Abel L" first="L" last="Abel">L. Abel</name><name sortKey="Jacobson, I M" sort="Jacobson, I M" uniqKey="Jacobson I" first="I M" last="Jacobson">I M Jacobson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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